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The signal is promising but not definitive
This is an important nuance: GLP-1 therapy, including orforglipron, is primarily a metabolic intervention
Not through standard clinical pathways
In fact, sun exposure is essential for mitochondrial health, vitamin D synthesis, immune function, and circadian regulation
PMID: 20591885 Fusco C, Morlino S, Micale L, Ferraris A, Grammatico P, Castori M
Since GLP-1 drugs also have an effect on inflammation and the immune system, theoretically combining them with biologics could create a heightened risk of infection or immune-related issues
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